Endocrine Abstracts

Aim: To describe the clinical course of an adolescent girl with gigantism.Background and methodsIn young persons with open epiphyses, overproduction of GH results in gigantism, with consequent longitudinal growth acceleration1. Pituitary gigantism is extremely rare, and its cause in the majority of patients is a pituitary adenoma1. Here, we present a 12, 5 years-old girl investigated for tall stature [183.5&#1...

Background: CHARGE is an autosomal-dominant syndrome which includes a variable combination of ocular coloboma, heart defects, atresia of the choanae, retardation of growth and development, and genitourinary and ear abnormalities CHARGE syndrome has rarely been associated with anterior pituitary dysfunction and with structural abnormalities of the pituitary gland only twice. We report the case of a child with CHARGE association and congenital hypopituitarism due to structural a...

Background: Adrenal venous sampling (AVS) is the gold standard method that evaluates the source of aldosterone overproduction in primary aldosteronism. During AVS aldosterone and cortisol are simultaneously measured in order to assess successful adrenal cannulation and lateralization of aldosterone overproduction. However, in patients with both adrenal cortisol and aldosterone overproduction, plasma metaneprhines and normetanephrines can be measured to overcome selectivity and...